SACTCheck Regimen-specific NCCP day-ward clinical decision support Developed by Dr Paul O’Brien
Feasibility study build v0.48.4

Feasibility evaluation build. Do not enter patient-identifiable information. SACTCheck highlights how clinician-entered information compares with encoded NCCP criteria; it does not prescribe, authorise or confirm treatment safety. Verify the current NCCP protocol and apply independent clinical judgement.

Clinician feasibility evaluation

Structured NCCP regimen assessment, in one place

Search the complete adult solid-tumour library, enter relevant clinical assessment information and review a transparent comparison with encoded protocol criteria. Official NCCP source access remains available throughout.

Quick-start guide
361canonical adult solid-tumour regimens
NCCPsource-linked protocol criteria
No patient-identifiable information requiredSACTCheck uses clinical assessment inputs only. Do not enter names, hospital numbers, dates of birth, contact details or other identifying information.
About the project

What SACTCheck is, and why it is being developed

An independently developed clinician-facing tool designed to make published NCCP regimen criteria easier to find, apply and document during structured oncology assessments.

01

What it does

SACTCheck converts source-linked NCCP regimen criteria into a transparent, structured comparison with clinician-entered laboratory and toxicity information. It shows which encoded criteria are met, not met or unassessed, while keeping the official protocol available for verification.

02

Why it was created

Day-ward decisions can require rapid review of regimen-specific thresholds, dose-modification guidance, treatment phase and toxicity criteria across lengthy protocol documents. The project aims to improve speed, consistency, transparency and documentation without replacing the treating clinician or the current NCCP source.

03

What is being evaluated

This feasibility build uses structured clinical scenarios to assess usability, completion time, clarity of outputs and agreement with independently adjudicated protocol-based answers before any consideration of routine clinical deployment.

1Find the regimen
2Enter assessment information
3Review criteria and unassessed domains
4Verify the official NCCP protocol

Regimen library

Find the current NCCP regimen, confirm the tissue-specific indication and open a structured day-ward assessment.

v0.48.4 · What changed?
Oral anti-cancer service and privacy wording update

Adds an oral anti-cancer medicines filter and card badge, expands oral-service search terms and introduces clearer instructions on patient-identifiable information. Protocol JSON and encoded clinical rules are unchanged.

Results update as you type. Press Enter to jump to the first match or / to focus search.

Browse by tumour site

Each tissue page carries a stable icon and colour throughout its catalogue section. Search still covers the entire library.

Visual navigation

Breast · Gynaecology · Lung · GU

Weekly paclitaxel

NCCP 00226 · Version 9

PACLitaxel 80 mg/m² on days 1, 8, 15 and 22 of a 28-day cycle.

Assessment availableClinical validation pending
Gastrointestinal

Modified FOLFOX-6

NCCP 00209 · Version 10a

Longitudinal blood-count tracking and component-specific dose modification.

Assessment availableClinical validation pending
Gastrointestinal

FOLFIRI

NCCP 00227 · Version 9

Irinotecan and 5-FU dose levels, delayed-count nadirs, diarrhoea, stomatitis, renal and hepatic rules.

Assessment availableClinical validation pending
Gynaecology

Carboplatin and paclitaxel

NCCP 00303 · Version 6

21-day regimen with carboplatin renal checks, hepatic paclitaxel dosing and neuropathy pathways.

Assessment availableClinical validation pending
Gynaecology

Carboplatin + pegylated liposomal doxorubicin

NCCP 00624 · Version 3

Platinum-sensitive relapse with haematology, hepatic, PPE, stomatitis and cardiac review pathways.

Assessment availableClinical validation pending
Gynaecology

Mirvetuximab soravtansine

Local/current source required

No current NCCP SACT regimen was located in the official gynaecology library. Add once the approved local or NCCP protocol is supplied.

Catalog only
Gastrointestinal

XELOX

NCCP 00321 · Version 9

Mixed IV and oral regimen with count nadirs, renal adjustment, hand-foot syndrome, diarrhoea, stomatitis and oxaliplatin neuropathy rules.

Assessment availableClinical validation pending
Gastrointestinal

FOLFIRINOX

NCCP 00329 · Version 9

Metastatic pancreatic cancer regimen with haematology, renal, hepatic, diarrhoea, stomatitis and oxaliplatin neuropathy rules.

Assessment availableClinical validation pending
Gastrointestinal

Modified FOLFIRINOX

NCCP 00515 · Version 7

Pancreatic cancer regimen with occurrence-based blood-count and component-specific dose modification.

Assessment availableClinical review pending
Gastrointestinal

Gemcitabine and cisplatin

NCCP 00383 · Version 8

Day 1/day 8 assessment with gemcitabine percentage dosing and cisplatin renal branching.

Assessment availableClinical review pending
Gastrointestinal

Cisplatin and 5-FU chemoradiation

Herskovic · NCCP 00460 · Version 4

Oesophageal chemoradiation with haematology, renal, hepatic and toxicity criteria.

Assessment availableClinical review pending
Lung

Pembrolizumab, pemetrexed and carboplatin

NCCP 00568 · Version 5

First-line metastatic non-squamous NSCLC without EGFR or ALK-positive mutations.

Assessment availableClinical review pending
Lung

Durvalumab maintenance

NCCP 00655 · Version 3a

Durvalumab 1500 mg every 28 days after concurrent platinum-based chemoradiation for Stage III NSCLC.

Assessment availableClinical review pending
Lung

Carboplatin and etoposide

NCCP 00271 · Version 6

21-day regimen for extensive-stage small-cell lung cancer, with IV or IV/oral etoposide schedules.

Assessment availableClinical review pending
← Regimen library
Protocol information and validation status
RegimenPACLitaxel monotherapy 80 mg/m²
NCCP code / version00226 / Version 9
ScheduleDays 1, 8, 15 and 22 — 28 days
Protocol review date14 April 2030
Source checkChecked against HSE PDF on 15 July 2026
Clinical validationPending consultant and oncology-pharmacy review

Boundary implementation: a platelet count of exactly 90 ×10⁹/L is assigned to the protocol row stating platelets ≥90. The subsequent row is implemented as 70 to <90 to avoid overlap.

Open source protocol

Assessment context

Step 1 of 5
Do not enter a name, MRN or date of birth.
Used for percentage-based hepatic modification.
Dose intended before today’s assessment.

Protocol exclusions

Step 2 of 5

Haematology

Step 3 of 5

Hepatic and renal review

Step 4 of 5

Laboratory profile: manual editable values. CUH defaults have not yet been formally configured; confirm each upper reference limit against the current laboratory report.

Bilirubin ratio0.50 × ULN
ALT ratio0.63 × ULN
AST ratio0.63 × ULN
Highest transaminase ratio0.63 × ULN

Adverse events

Step 5 of 5
← Regimen library
Protocol information and validation status
RegimenFOLFOX-6 Modified Therapy — 14 day
NCCP code / version00209 / Version 10a
Tumour groupGastrointestinal
Protocol review date31 October 2030
Source checkChecked against HSE PDF on 15 July 2026
Clinical validationPending consultant and oncology-pharmacy review

Scope of this prototype: day-1 haematology and delayed-week nadirs, renal/hepatic impairment, DPD status, neuropathy, diarrhoea, stomatitis, laryngo-pharyngeal dysaesthesia and pulmonary warning symptoms. Any modification should be discussed with a Consultant.

Open source protocol

Assessment context and current doses

Step 1 of 4
Do not enter a name, MRN or date of birth.
Use 0 when this is not a repeat after delay.

Baseline and protocol checks

Step 2 of 4

Haematology and organ function

Step 3 of 4
Hold on day 1 if below 1.5.
Hold on day 1 if below 75.
Determines subsequent component dosing after a delay.

Regimen-specific toxicity

Step 4 of 4

Peripheral neuropathy and oxaliplatin warnings

Used only when grade 3 is selected.

Diarrhoea

Stomatitis and PPE

← Regimen library
Protocol information and validation status
RegimenFOLFIRI Therapy — 14 day
NCCP code / version00227 / Version 9
Tumour groupGastrointestinal
Review date27 January 2030
Rule-pack statusAutomated tests complete; clinical review pending

Scope: haematology and delayed-week nadirs, DPD status, renal/hepatic impairment, diarrhoea and stomatitis.

Open source protocol

Assessment context and current doses

Step 1 of 4

Protocol checks

Step 2 of 4

Bloods and organ function

Step 3 of 4

Current and previous toxicity

Step 4 of 4
← Regimen library
Protocol information and URO status
RegimenCapecitabine and Oxaliplatin Therapy (XELOX)
NCCP code / version00321 / Version 9
ScheduleOxaliplatin day 1; capecitabine days 1–14; 21-day cycle
Review date11 November 2030
ArchitectureUniversal Regimen Object v1
ValidationAutomated prototype tests complete; clinical review pending
Open source protocol

Assessment context

Step 1 of 4

Bloods and organ function

Step 2 of 4

Clinical toxicities

Step 3 of 4

Assessment

Step 4 of 4
Protocol information
RegimenModified FOLFIRINOX
NCCP00515 · Version 7
IndicationMetastatic pancreatic adenocarcinoma
Clinical reviewPending consultant and oncology-pharmacy review
Open current NCCP protocol

Modified FOLFIRINOX assessment

Demonstration prototype
Protocol information
RegimenGemcitabine and cisplatin
NCCP00383 · Version 8
IndicationAdvanced biliary tract cancer
Clinical reviewPending consultant and oncology-pharmacy review
Open current NCCP protocol

Gemcitabine and cisplatin assessment

Demonstration prototype
Protocol information
RegimenCisplatin and 5-FU chemoradiation — Herskovic
NCCP00460 · Version 4
IndicationOesophageal carcinoma treated with definitive chemoradiation
Clinical reviewPending consultant and oncology-pharmacy review
Open current NCCP protocol

Cisplatin and 5-FU chemoradiation — Herskovic assessment

Demonstration prototype
Protocol publisher v0.31.0

Validate and preview a protocol JSON file

This validates the file locally in this browser. It does not upload patient information or permanently publish a protocol.

Use a reviewed SACTCheck schema 2.x protocol file.

Preview here first. To publish for all users, place the validated JSON under protocols/ and push it. The repository workflow validates it and rebuilds protocols/index.json.

Protocol information and indication
RegimenPembrolizumab, pemetrexed and carboplatin AUC 5
NCCP code / version00568 / Version 5
ScheduleEvery 21 days
Combination phaseUp to 4 cycles, then pembrolizumab + pemetrexed maintenance
Clinical reviewPending consultant and oncology-pharmacy review

Protocol and treatment context

First-line metastatic non-squamous NSCLC without sensitising EGFR mutation or ALK translocation.

Blood results and organ function

Clinical toxicity assessment

Protocol information and indication
RegimenDurvalumab monotherapy 1500 mg
NCCP code / version00655 / Version 3a
ScheduleEvery 28 days, maximum 12 months / 13 cycles
TimingCycle 1 within 42 days of completing concurrent chemoradiotherapy
Clinical reviewPending consultant and oncology-pharmacy review

Protocol and treatment context

Current clinical assessment

Protocol information and indication
RegimenCarboplatin AUC 5 and etoposide 100 mg/m²
NCCP code / version00271 / Version 6
ScheduleDays 1–3, every 21 days for 4–6 cycles
IndicationExtensive-stage small-cell lung cancer
Clinical reviewPending consultant and oncology-pharmacy review

Protocol and treatment context

Blood results and organ function

Copied
Protocol information and indication
RegimenCarboplatin AUC 5–7.5 and paclitaxel 175 mg/m²
NCCP code / version00303 / Version 6
ScheduleDay 1 every 21 days, usually 6 cycles
Clinical reviewPending consultant and oncology-pharmacy review

Protocol and treatment context

Blood results and organ function

Clinical toxicity assessment

Protocol information and indication
RegimenCarboplatin AUC 5 + pegylated liposomal doxorubicin 30 mg/m²
NCCP code / version00624 / Version 3
ScheduleDay 1 every 28 days, generally 6 cycles
Clinical reviewPending consultant and oncology-pharmacy review

Protocol and treatment context

Blood results and organ function

Clinical toxicity assessment