:root{
  --ink:#163447;--muted:#56707d;--line:#d7e3e7;--paper:#fff;--bg:#f4f8f8;
  --navy:#11384d;--teal:#0b7a78;--teal-soft:#eaf5f4;--purple:#653298;--purple-soft:#f2ebfa;
  --amber:#a9600b;--amber-soft:#fff3df;--red:#a32636;--red-soft:#fff0f2;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;background:var(--bg);color:var(--ink);font:16px/1.58 system-ui,-apple-system,Segoe UI,sans-serif}
a{color:#08637a;text-underline-offset:3px}
a:focus-visible,button:focus-visible,summary:focus-visible{outline:3px solid #c16d00;outline-offset:3px}
.wiki-shell{max-width:1100px;margin:auto;padding:0 22px}
.wiki-top{background:#0f2f42;color:#fff;padding:10px 0}
.wiki-top .wiki-shell{display:flex;justify-content:space-between;gap:14px;align-items:center;flex-wrap:wrap}
.wiki-brand{font-size:12px;font-weight:850;letter-spacing:.13em}
.wiki-top a{color:#d8eeef;font-size:13px}
.wiki-hero{background:linear-gradient(120deg,#12374b 0%,#105f69 64%,#0a817c 100%);color:#fff;padding:46px 0 38px;position:relative;overflow:hidden}
.wiki-hero:after{content:"";position:absolute;width:260px;height:260px;border-radius:50%;right:-55px;top:-65px;background:#ffffff0d}
.wiki-eyebrow{font-size:12px;font-weight:850;letter-spacing:.13em;text-transform:uppercase;color:#d8f3ef}
.wiki-hero h1{font-size:clamp(2.15rem,5vw,4rem);line-height:1.02;letter-spacing:-.045em;margin:10px 0 14px;max-width:930px}
.wiki-hero p{max-width:850px;color:#e4f0f1;font-size:1.08rem;margin:0 0 18px}
.wiki-tags,.wiki-actions,.wiki-source-chips{display:flex;gap:8px;flex-wrap:wrap}
.wiki-tag{border:1px solid #ffffff55;border-radius:999px;padding:6px 11px;font-size:13px}
.wiki-actions{margin-top:18px;position:relative;z-index:2}
.wiki-btn{display:inline-flex;align-items:center;gap:6px;border-radius:9px;padding:10px 14px;text-decoration:none;font-weight:800;background:#fff;color:var(--navy);border:1px solid #ffffff66}
.wiki-btn.alt{background:transparent;color:#fff}
.wiki-btn.teal{background:var(--teal);color:#fff;border-color:var(--teal)}
.wiki-btn.ghost{background:#fff;color:var(--ink);border-color:var(--line)}
.wiki-sourcebar{background:#fff;border-bottom:1px solid var(--line)}
.wiki-sourcebar .wiki-shell{display:flex;gap:16px;align-items:center;justify-content:space-between;padding-top:12px;padding-bottom:12px}
.wiki-sourcebar strong{font-size:13px}
.wiki-sourcebar span{font-size:12px;color:var(--muted)}
.wiki-source-chip{display:inline-block;border:1px solid #bdd4d6;background:#f5fbfb;border-radius:999px;padding:5px 9px;font-size:12px;font-weight:750;text-decoration:none;white-space:nowrap}
.wiki-nav{position:sticky;top:0;z-index:10;background:#ffffffef;backdrop-filter:blur(8px);border-bottom:1px solid var(--line)}
.wiki-nav .wiki-shell{display:flex;gap:16px;overflow-x:auto;white-space:nowrap;padding-top:10px;padding-bottom:10px;scrollbar-width:none}
.wiki-nav .wiki-shell::-webkit-scrollbar{display:none}
.wiki-nav a{text-decoration:none;font-size:13px;font-weight:800;color:#235061}
.wiki-section{padding:42px 0;border-bottom:1px solid var(--line);scroll-margin-top:60px}
.wiki-kicker{font-size:12px;font-weight:850;letter-spacing:.12em;text-transform:uppercase;color:var(--teal)}
.wiki-section h2{font-size:clamp(1.7rem,3.6vw,2.55rem);line-height:1.08;letter-spacing:-.035em;margin:5px 0 12px}
.wiki-section h3{margin:0 0 8px;line-height:1.25}
.wiki-lead{font-size:1.05rem;color:var(--muted);max-width:860px;margin:0 0 18px}
.wiki-atglance{display:grid;grid-template-columns:1.2fr .8fr;gap:16px;margin-top:20px}
.wiki-panel{background:#fff;border:1px solid var(--line);border-radius:15px;padding:18px}
.wiki-panel strong{color:#153e53}
.wiki-facts{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:10px}
.wiki-fact{background:#f7fafb;border:1px solid #e0eaed;border-radius:11px;padding:12px}
.wiki-fact span{display:block;font-size:11px;text-transform:uppercase;letter-spacing:.08em;color:#6c808a;font-weight:800}
.wiki-fact b{display:block;margin-top:3px;font-size:14px}
.wiki-evidence{border-left:5px solid var(--teal);background:#eef8f7}
.wiki-evidence p{margin:7px 0}
.wiki-evidence .wiki-small{font-size:13px;color:var(--muted)}
.wiki-drugs{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:14px;margin-top:20px}
.wiki-drug{background:#fff;border:1px solid var(--line);border-radius:15px;padding:18px;position:relative;overflow:hidden}
.wiki-drug:before{content:"";position:absolute;inset:0 0 auto 0;height:5px;background:var(--teal)}
.wiki-drug.immune:before{background:var(--purple)}
.wiki-drug.platinum:before{background:var(--amber)}
.wiki-drug-type{font-size:11px;font-weight:850;letter-spacing:.09em;text-transform:uppercase;color:#6b7c85;margin-top:4px}
.wiki-drug h3{font-size:1.35rem;margin-top:4px}
.wiki-drug .alias{font-size:13px;color:var(--muted);margin-top:-5px}
.wiki-diagram{width:100%;height:105px;display:block;margin:7px 0 4px}
.wiki-mechanism{display:grid;grid-template-columns:1fr auto 1fr auto 1fr;gap:6px;align-items:center;text-align:center;margin:12px 0}
.wiki-mechanism span{background:#f1f6f7;border-radius:7px;padding:7px 5px;font-size:12px}
.wiki-mechanism b{color:var(--teal)}
.wiki-drug.immune .wiki-mechanism b{color:var(--purple)}
.wiki-watch{border-top:1px solid var(--line);padding-top:10px;margin-top:10px;font-size:14px}
.wiki-journey{display:grid;grid-template-columns:repeat(5,minmax(0,1fr));gap:10px;margin-top:20px}
.wiki-step{background:#fff;border:1px solid var(--line);border-top:4px solid var(--teal);border-radius:12px;padding:13px;min-height:145px}
.wiki-step b{display:block;color:#155267;margin-bottom:5px}.wiki-step p{font-size:13px;margin:0;color:#4c6470}
.wiki-patterns{display:grid;grid-template-columns:repeat(4,minmax(0,1fr));gap:10px;margin-top:16px}
.wiki-pattern{background:#fff;border:1px solid var(--line);border-radius:11px;padding:13px}
.wiki-pattern strong{display:block;font-size:13px;margin-bottom:4px;color:#124b5f}.wiki-pattern p{font-size:13px;margin:0;color:var(--muted)}
.wiki-pattern.anytime{border-color:#d6c3eb;background:#fbf8fe}.wiki-pattern.anytime strong{color:var(--purple)}
.wiki-note{border-radius:12px;padding:14px 17px;margin-top:17px;background:var(--teal-soft);border-left:5px solid var(--teal)}
.wiki-note.warn{background:var(--amber-soft);border-left-color:var(--amber)}
.wiki-note.urgent{background:var(--red-soft);border-left-color:var(--red)}
.wiki-note.urgent strong{color:var(--red)}
.wiki-side-effects{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px;margin-top:16px}
.wiki-side-card{background:#fff;border:1px solid var(--line);border-radius:12px;padding:15px}.wiki-side-card h3{font-size:1rem}.wiki-side-card ul{padding-left:18px;margin:8px 0 0}.wiki-side-card li{margin:5px 0;font-size:13px}
.wiki-side-card.immune{border-top:4px solid var(--purple)}.wiki-side-card.chemo{border-top:4px solid var(--teal)}.wiki-side-card.platinum{border-top:4px solid var(--amber)}
.wiki-support{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:12px}.wiki-support .wiki-panel h3{font-size:1rem}.wiki-support .wiki-panel p,.wiki-support li{font-size:14px}.wiki-support ul{padding-left:18px;margin-bottom:0}
.wiki-contact-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:10px;margin-top:15px}.wiki-contact{background:#fff;border:1px solid #e4c7ca;border-radius:11px;padding:13px}.wiki-contact span{display:block;font-size:11px;text-transform:uppercase;font-weight:850;color:#7b5158}.wiki-contact b{display:block;margin:4px 0;color:#8e1f30}.wiki-contact p{font-size:13px;margin:0;color:var(--muted)}
.wiki-tools{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:12px}.wiki-tool{background:#fff;border:1px solid var(--line);border-radius:13px;padding:17px}.wiki-tool h3{font-size:1.05rem}.wiki-tool p{font-size:14px;color:var(--muted)}
.wiki-faq details{background:#fff;border:1px solid var(--line);border-radius:10px;padding:14px 16px;margin:8px 0}.wiki-faq summary{font-weight:800;cursor:pointer}.wiki-faq p{margin-bottom:0;color:#4c6370}
.wiki-sources{display:grid;gap:9px}.wiki-source{background:#fff;border:1px solid var(--line);border-radius:10px;padding:12px 14px}.wiki-source b{display:block;font-size:14px}.wiki-source p{font-size:12px;color:var(--muted);margin:3px 0 0}
.wiki-footer{padding:25px 0 38px;font-size:12px;color:#617681}
.wiki-anatomy-wrap{margin-top:20px}.wiki-anatomy-wrap .patient-bodymap-card{background:#fff}
.wiki-anatomy-wrap .hcc-visual-title h4{font-size:1.4rem}.wiki-anatomy-wrap .hcc-visual-title p{font-size:14px}
.wiki-anatomy-wrap .hcc-organ-card p{font-size:13px}
@media(max-width:900px){.wiki-atglance{grid-template-columns:1fr}.wiki-drugs,.wiki-side-effects,.wiki-tools{grid-template-columns:1fr}.wiki-journey{grid-template-columns:repeat(2,1fr)}.wiki-patterns{grid-template-columns:repeat(2,1fr)}.wiki-contact-grid{grid-template-columns:1fr}.wiki-support{grid-template-columns:1fr}}
@media(max-width:620px){.wiki-shell{padding:0 17px}.wiki-hero{padding:32px 0 28px}.wiki-sourcebar .wiki-shell{align-items:flex-start;flex-direction:column}.wiki-facts{grid-template-columns:1fr}.wiki-journey,.wiki-patterns{grid-template-columns:1fr}.wiki-mechanism{grid-template-columns:1fr}.wiki-mechanism b{transform:rotate(90deg)}.wiki-section{padding:32px 0}.wiki-actions{display:grid}.wiki-btn{justify-content:center}.wiki-nav{position:static}.wiki-nav .wiki-shell{padding-top:9px;padding-bottom:9px}.wiki-anatomy-wrap{overflow:hidden}}
@media print{.wiki-top,.wiki-nav,.wiki-actions{display:none!important}.wiki-hero{background:#fff;color:var(--ink);padding:20px 0}.wiki-hero p{color:var(--muted)}.wiki-tag{border-color:#aaa}.wiki-section{padding:20px 0}.wiki-panel,.wiki-drug,.wiki-step,.wiki-side-card,.wiki-tool,.wiki-source,details{break-inside:avoid}.wiki-shell{max-width:none}.wiki-journey,.wiki-drugs,.wiki-side-effects,.wiki-tools{grid-template-columns:repeat(2,1fr)}a{color:inherit}}