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Pembrolizumab 200 mg + carboplatin AUC 5 / paclitaxel → AC
NCCP 00857 v3 · 21-day cycle
Four 21-day cycles: paclitaxel on Days 1, 8 and 15; carboplatin AUC 5 on Day 1. Pembrolizumab 200 mg on Day 1 of each cycle (every three weeks). Four further cycles (cycles 5–8): doxorubicin and cyclophosphamide on Day 1 every 21 days. Pembrolizumab 200 mg on Day 1 of each AC cycle. After surgery: pembrolizumab 200 mg every 21 days for nine doses OR 400 mg every 42 days for five doses. These are alternative schedules, not consecutive courses. Progression preventing definitive surgery or unacceptable pembrolizumab toxicity changes this plan; postoperative treatment is not automatic.

Oncology team: Insert numbers here
Out of hours: Insert numbers here.
Evenings / overnight: instructed out-of-hours pathway or nearest ED.
Emergency: 112 / 999.
Other hospital / own contact: ____________________
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